PSD-95 REGULATES SEROTONIN RECEPTOR FUNCTION IN VIVO by ATHEIR
نویسندگان
چکیده
We hereby approve the dissertation of Atheir Ibrahim Abbas
منابع مشابه
PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors.
Here, we report that postsynaptic density protein of 95 kDa (PSD-95), a postsynaptic density scaffolding protein, classically conceptualized as being essential for the regulation of ionotropic glutamatergic signaling at the postsynaptic membrane, plays an unanticipated and essential role in mediating the actions of hallucinogens and atypical antipsychotic drugs at 5-HT(2A) and 5-HT(2C) serotone...
متن کاملA direct interaction of PSD-95 with 5-HT2A serotonin receptors regulates receptor trafficking and signal transduction.
The serotonin (5-hydroxytryptamine) 2A receptor (5-HT2A) is an important G protein-coupled receptor (GPCR) that mediates the effects of hallucinogens and is the target of a number of commonly prescribed medications including atypical antipsychotics, antidepressants, and anxiolytics. The 5-HT2A receptor possesses a canonical Type I PDZ-binding domain (X-Ser/Thr-X-Phi) at the carboxyl terminus an...
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Cyclin-dependent kinase 5 (Cdk5) and its activator p35 have been implicated in drug addiction, neurodegenerative diseases such as Alzheimer's, learning and memory, and synapse maturation and plasticity. However, the molecular mechanisms by which Cdk5 regulates synaptic plasticity are still unclear. PSD-95 is a major postsynaptic scaffolding protein of glutamatergic synapses that regulates synap...
متن کاملNeurobiology of Disease PSD-95 Is Essential for Hallucinogen and Atypical Antipsychotic Drug Actions at Serotonin Receptors
Atheir I. Abbas,1* Prem N. Yadav,2* Wei-Dong Yao,7,8,9,10 Margaret I. Arbuckle,11 Seth G. N. Grant,11,12 Marc G. Caron,7,8,9 and Bryan L. Roth1,2,3,4,5,6 1Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, Departments of 2Pharmacology, 3Medicinal Chemistry, and 4Psychiatry, 5Lineberger Cancer Center, and 6National Institute of Mental Health Ps...
متن کاملPhosphorylation of the postsynaptic density-95 (PSD-95)/discs large/zona occludens-1 binding site of stargazin regulates binding to PSD-95 and synaptic targeting of AMPA receptors.
Dynamic regulation of AMPA-type receptors at the synapse is proposed to play a critical role in alterations of the synaptic strength seen in cellular models of learning and memory such as long-term potentiation in the hippocampus. Stargazin, previously identified as an AMPA receptor (AMPAR)-interacting protein, is critical for surface expression and synaptic targeting of AMPARs. Stargazin inter...
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